The Gulf of Mexico is a vast and productive body of water spanning 600,000 square miles with tremendous ecological, economic, and social value. The vast Gulf provides essential habitat for an amazing diversity of fish, whales, dolphins, and species of migratory, wading, and sea birds. Unfortunately, marine debris impacts habitats, wildlife, and industries throughout the Gulf of Mexico. In order to address the issue of marine debris, from large hurricane debris to tiny microplastics, the region needs a comprehensive approach that brings together many partners.